Sulforaphane as discussed on Joe Rogan with Dr Rhonda Patrick

Sulforaphane as a Nootropic? The inflammation factor

     Sulforaphane is a compound commonly found in many cruciferous vegetables with potentially strong anti-inflammatory, possibly nootropic properties, with use in autism research, making it an interesting substance for many supplement users and nootropics fans. After being discussed for its health benefits and potential as a nootropic Dr. Rhonda Patrick and Joe Rogan on a recent podcast (January 2017) explain its possible mechanisms of action and chemical properties. This has caused the compound to see an uptick in interest and media attention for its potential benefits. [1]
     On the podcast, Dr. Rhonda Patrick speculates about the potential for sulforaphane to function as a nootropic by inhibiting inflammation. Its effects on inflammation are well documented, and inflammations negative impact on cognitive functioning and implication in many degenerative neurological conditions is also well noted, so it seems that it would be a natural fit as a nootropic. Inflammation has been associated with illnesses such as schizophrenia, dementia, traumatic brain injury, Alzheimer’s, and others. Dr. Rhonda Patrick also talks about its benefits related to the mitigation of oxidative stress, and benzene metabolism.
sulforaphane rhonda patrick

Activating Sulforaphane

Sulforaphane is actually produced during the interaction between the enzyme myrosinase and glucoraphanin during damage to the plant such as chewing or breaking. Freezing is another type of damage commonly used to elicit the reaction, yielding high levels particularly in young broccoli sprouts. Myrosinase is heat sensitive, meaning that cooking these plants eliminates the potential for the formation of sulforaphane.

Other potential benefits

Sulforaphane has shown promise in research for depression, autism, neuro-degenerative diseases, thought to be attributable to its modulation if nrf-2, responsible for its effects on inflammation. It has also shown potential in cancer research. [2] Its overall benefits as an antioxidant, anti-inflammatory, and potential nootropic make it an interesting and potentially popular supplement for coming years.